Spanish conquistadors, pirate attacks, yellow fever, revolution...Ecuador's largest city boasts a long and colorful history! Dating back to 1538, Guayaquil is situated near the Equator on the Guayas River and is the country's main port and jumping-off point for cruises to the Galápagos Islands. Main attractions include the Old Town, Las Peñas, for a glimpse into the city's colonial past; Parque de las Iguanas, home to hundreds of tame iguanas; Santa Ana Hill for sweeping views of Guayaquil; the Mercado Artesanal, selling hand-crafted souvenirs from all around the country; and swimming, watersports, and delicious fresh seafood at the General Villamil beach.

At Monograms, we have more than 90 years of travel experience and expertise behind us. You can rely on experts to help you plan and book your . Once you're there, we're ready to help you each step of the way with support that takes the worry out of travel.

Ecuador Discovery (ISE)

9 Day Package from Quito to Guayaquil

Starting at $2,889

per person, without air*

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$33/city*

Cruising the Galápagos on the Galápagos Legend (ISK)

7 Day Package from Quito to Guayaquil

Starting at $3,079

per person, without air*

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$33/city*

Galápagos Highlights (ISQ)

8 Day Package from Quito to Guayaquil

Starting at $3,599

per person, without air*

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$19/city*

Ecuador Discovery with Ecuador's Amazon (ISEC)

13 Day Package from Quito to Guayaquil

Starting at $4,519

per person, without air*

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Cruising the Galápagos on the Galápagos Legend with Ecuador's Amazon (ISKC)

11 Day Package from Quito to Guayaquil

Starting at $4,709

per person, without air*

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Cruising the Galápagos on board the Santa Cruz II (ISW)

8 Day Package from Quito to Guayaquil

Starting at $4,743

per person, without air*

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Galápagos Highlights with Ecuador's Amazon (ISQC)

12 Day Package from Quito to Guayaquil

Starting at $5,229

per person, without air*

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Cruising the Galápagos on board the Coral - 7 Night cruise (ISZ)

11 Day Package from Quito to Guayaquil

Starting at $5,329

per person, without air*

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$33/city*

Ecuador Discovery with the Finch Bay in the Galápagos (ISEG)

14 Day Package from Quito to Guayaquil

Starting at $5,829

per person, without air*

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Journey through the Andes with the Finch Bay in the Galápagos (ISNE)

19 Day Package from Lima to Guayaquil

Starting at $6,283

per person, without air*

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Cruising the Galápagos on board the Santa Cruz II with Ecuador's Amazon (ISWC)

12 Day Package from Quito to Guayaquil

Starting at $6,373

per person, without air*

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$19/city*

Grand Tour of South America with the Finch Bay in the Galápagos (ISGF)

23 Day Package from Rio de Janeiro to Guayaquil

Starting at $6,793

per person, without air*

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Journey through the Andes with Peru's Amazon & the Finch Bay in the Galápagos (ISNJ)

22 Day Package from Lima to Guayaquil

Starting at $6,913

per person, without air*

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Cruising the Galápagos on board the Coral - 7 Night cruise with Ecuador's Amazon (ISZC)

15 Day Package from Quito to Guayaquil

Starting at $6,959

per person, without air*

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$26/city*

Ecuador Discovery with Galápagos Cruise on the Santa Cruz II (ISEE)

14 Day Package from Quito to Guayaquil

Starting at $7,053

per person, without air*

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Grand Tour of South America with Salvador & the Finch Bay in the Galápagos (ISGT)

25 Day Package from Salvador to Guayaquil

Starting at $7,225

per person, without air*

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Journey through the Andes with the Galápagos on board the Santa Cruz II (ISNC)

19 Day Package from Lima to Guayaquil

Starting at $7,367

per person, without air*

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Ecuador Discovery with Ecuador's Amazon & the Finch Bay in the Galápagos (ISEJ)

18 Day Package from Quito to Guayaquil

Starting at $7,459

per person, without air*

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$33/city*

Grand Tour of South America with the Galápagos on board the Santa Cruz II (ISGG)

23 Day Package from Rio de Janeiro to Guayaquil

Starting at $7,884

per person, without air*

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Grand Tour of South America with Brazil's Amazon & the Finch Bay in the Galápagos (ISHF)

26 Day Package from Manaus to Guayaquil

Starting at $7,893

per person, without air*

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Journey through the Andes with Peru's Amazon & the Galápagos on the Santa Cruz II (ISNH)

22 Day Package from Lima to Guayaquil

Starting at $7,997

per person, without air*

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Grand Tour of South America with Salvador & the Galápagos on board the Santa Cruz II (ISGU)

25 Day Package from Salvador to Guayaquil

Starting at $8,316

per person, without air*

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Ecuador Discovery with Ecuador's Amazon & Galápagos Cruise on the Santa Cruz II (ISEH)

18 Day Package from Quito to Guayaquil

Starting at $8,683

per person, without air*

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$33/city*

Grand Tour of South America with Brazil's Amazon & the Galápagos on board the Santa Cruz II (ISHG)

26 Day Package from Manaus to Guayaquil

Starting at $8,984

per person, without air*

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* The "Starting at" or listed price is based on the lowest price available to book. Price is per passenger based on double occupancy and does not include airfare; additional fees/charges are not included. Pricing may vary on this date due to hotel availability. If a price is crossed out, the new price includes a limited time promotional offer(s) – please review current promotions or deals for additional information. Some packages require intra-vacation flights (and in some cases intra-vacation segments must be purchased from Monograms).